Functional neuroimaging studies in functional dyspepsia patients: a systematic review
Item
Title
Functional neuroimaging studies in functional dyspepsia patients: a systematic review
Author(s)
Journal Publication
Date
2016
volume
28(6)
pages
793-805
Research Type
Systematic Review
Keywords
Abstract
BACKGROUND: There is increasing evidence in support of the presence of abnormal central changes (compared to healthy controls) in functional dyspepsia (FD) in addition to the peripheral changes in gastrointestinal tract. PURPOSE: This systematic review aims to provide an integrative understanding of the abnormal functional brain activity, visceral sensation, dyspeptic symptoms, and psychological changes of FD. Electronic and hand searches were conducted to identify functional neuroimaging studies involving FD patients. Sixteen studies were selected and divided into three categories: 10 resting state studies, three visceral distention studies, and three acupuncture studies. Changes were reported in several brain areas in FD patients including the frontal cortex, somatosensory cortex, insula, anterior cingulate cortex, thalamus, hippocampus, and amygdala. These brain activity changes were associated with visceral hypersensitivity, dyspeptic symptoms, poorer quality of life, anxiety, and depression. The results show that FD is associated with functional abnormalities in sensory and pain modulation, emotion, saliency, and homeostatic processing regions. The diversity of conditions, heterogeneous results, poorly standardized diagnoses of FD, and various comorbidities may be responsible for the variability in the results.
doi
10.1111/nmo.12793
pmid
PMID:26940430
View on Pubmed
Language
English
has health condition studied
Gastrointestinal Diseases
has study population number
0